Ciekawostka: Your stomach has to produce a new layer of mucus every 2 weeks otherwise it will digest itself

Evidence: 41 • authority: 88

Effect of 10% Ethanol and Sofalcone on Prostaglandin E ₂ Content, Mucus Gel Thickness, and Experimental Ulcers in the Stomach of Developing Rats. We studied the effects of a mild irritant, 10% ethanol, and sofalcone on the gastric mucosal defense mechanisms in newborn rats, comparing the effects to those seen in adult rats. The results indicated (1) that both mucosal prostaglandin E₂ (PGE₂) content and mucus gel layer thickness increased with age, (2) that sofalcone, but not 10% ethanol, increased mucosal PGE2 content and mucus gel thickness in 1- and 8-week-old rats, (3) that both sofalcone and 10% ethanol decreased mucosal damage induced by 50 or 75% ethan…

Evidence: 22 • authority: 88

Metal Absorption and the Intestinal Mucus Layer. The luminal mucus layer of the rat’s small intestine was separated from the mucosa by filling the lumen with agar jelly. When the rats were fasted overnight and given 59Fe or 65Zn by stomach tube the mucus isolated by this technique contained more isotope and more sialic acid than fed controls, and more of the isotope was absorbed into the tissues. Saturation and time-course studies showed that the mucus layer has metal-binding activity distinct from that of the mucosa and it is postulated that the mucus layer may play a role in the process of metal absorption.

Evidence: — • authority: 35