Ciekawostka: The average life of a taste bud is 10 days

Evidence: 45 • authority: 92

Molecular Mechanisms of Age-Related Taste Dysfunction Deciphered by Spatiotemporal Transcriptomics.. Age-related taste dysfunction impairs nutrition and quality of life, contributing to metabolic disorders and frailty in the elderly, yet its cellular and molecular basis remains poorly understood. By integrating single-cell RNA and spatial transcriptomics sequencing, we systematically mapped murine taste bud aging across five developmental stages from neonatal to aged. Our findings reveal that age-associated taste impairment is driven by the progressive depletion of stem/progenitor cell differentiation capacity, predominantly characterized in the posterior tongue, and mediated by inflamm-agi…

Evidence: 33 • authority: 80

Control Mechanisms in Taste Bud Development

Evidence: 33 • authority: 92

Prox1 maintains taste bud structure via inhibition of apoptosis.. Taste buds are maintained by continuous cell renewal, receiving a steady influx of postmitotic cells from the surrounding epithelial region. Within taste buds, Type I, II, and III cells continuously differentiate from Type IV postmitotic precursor cells and are removed via apoptosis. These processes are likely governed by various transcription factors. Among the transcription factors expressed in taste buds, Prox1, a homeobox transcription factor, is the only factor expressed in all taste bud cells including precursor cells. However, its role in taste buds remains unclear. Here, we investigate the function of Prox1 in taste b…

Evidence: 33 • authority: 92

Tyrosine kinase inhibitors affect sweet taste and dysregulate fate selection of specific taste bud cell subtypes via KIT inhibition.. Taste dysfunction, or dysgeusia, is a common side effect of many cancer drugs. Dysgeusia is often reported by people treated with anti-angiogenic tyrosine kinase inhibitors (TKIs), which inhibit receptor tyrosine kinases (RTKs). However, the mechanisms by which TKIs cause dysgeusia are not understood, as the role of RTKs in adult taste homeostasis is unknown. Here, we find that treating adult mice with the TKI cabozantinib shifts the fate of differentiating functional taste cell subtypes within taste buds. Through behavioral assays, we find this cell fate shi…

Evidence: 33 • authority: 84

Establishment of a Three-Dimensional In Vitro Model of Taste Bud Cells for Fat Taste Investigation. Journal: International journal of molecular sciences. Year: 2026

Evidence: — • authority: 35