rośliny-i-grzyby: Hallucinogen

Evidence: 100 • authority: 72

Hallucinogens, also known as psychedelics, entheogens, or historically as psychotomimetics, are a broad and diverse class of psychoactive drugs that can induce altered states of consciousness characterized by marked changes in perception, mood, cognition, and self-experience, along with a range of other psychological alterations. Hallucinogens are often categorized as either being psychedelics, dissociatives, or deliriants, but not all hallucinogens fall into these three classes.

Evidence: 71 • authority: 72

Psychedelics are a subclass of hallucinogenic drugs whose primary effect is to trigger non-ordinary mental states (known as psychedelic experiences or "trips") and a perceived "expansion of consciousness". Also referred to as classic hallucinogens or serotonergic hallucinogens, the term psychedelic is sometimes used more broadly to include various other types of hallucinogens as well, such as those which are atypical or adjacent to psychedelia like ketamine and MDMA, respectively. They are widely illegal to sell, possess, or to prescribe; but are nevertheless part of the global illegal drug trade. Classic psychedelics generally cause specific psychological, visual, and auditory changes, and…

Evidence: 56 • authority: 92

Clinical applications of hallucinogens: A review.. Hallucinogens fall into several different classes, as broadly defined by pharmacological mechanism of action, and chemical structure. These include psychedelics, entactogens, dissociatives, and other atypical hallucinogens. Although these classes do not share a common primary mechanism of action, they do exhibit important similarities in their ability to occasion temporary but profound alterations of consciousness, involving acute changes in somatic, perceptual, cognitive, and affective processes. Such effects likely contribute to their recreational use. However, a growing body of evidence indicates that these drugs may have therapeutic app…

Evidence: 51 • authority: 88

Psychedelics and hallucinogens. Abstract The defining characteristic of this group of drugs is their ability to induce profound changes in sensory perception, patterns of thinking, and emotion without at the same time clouding the mind. Terminology is difficult, because it always seems to be judgement-laden; one person’s psychotomimetic (psychosis mimicker) is another’s psycholytic (literally mind loosener, and by implication, consciousness expander). Hallucinogen is a widely used label derived from the Latin alucinari (‘to wander in the mind’), which somehow fails to do justice to the complexity of the human response to these substances. The term true hallucinogen is perhaps most appropria…

Evidence: 46 • authority: 72

Ibogaine is a psychoactive indole alkaloid derived from plants such as Tabernanthe iboga, characterized by hallucinogenic and oneirogenic effects. Ibogaine exhibits complex pharmacology by interacting with multiple neurotransmitter systems, notably affecting opioid, serotonin, sigma, NMDA, and nicotinic acetylcholine receptors; its metabolite noribogaine primarily acts as a serotonin reuptake inhibitor and κ-opioid receptor agonist. The psychoactivity of the root bark of the iboga tree, T. iboga, one of the plants from which ibogaine is extracted, was first discovered by forager tribes in Central Africa, who passed the knowledge to the Bwiti tribe of Gabon. It was first documented in the 19…

Evidence: 42 • authority: 92

Hallucinations and Hallucinogens: Psychopathology or Wisdom?. Hallucinations are currently associated almost exclusively with psychopathological states. While it is evident that hallucinations can indicate psychopathology or neurological disorders, we should remember that hallucinations also commonly occur in people without any signs of psychopathology. A similar case occurs in the case of hallucinogenic drugs, which have been long associated with psychopathology and insanity. However, during the last decades a huge body of research has shown that certain kinds of hallucinations, exerted by hallucinogenic drugs, may serve to improve mental health. We propose that, in light of historical, ep…

Evidence: 37 • authority: 72

Lysergic acid diethylamide, commonly known as LSD (from German Lysergsäurediethylamid) and by the nicknames acid and Lucy, is a semisynthetic psychedelic drug derived from ergot, known for its potent psychological effects. LSD taken orally has an onset of action of 0.4 to 1.0 hours and a duration of 7 to 12 hours. In recreational settings it is commonly administered via tabs of blotter paper. LSD is extremely potent, with noticeable effects at doses as low as 20 micrograms and is sometimes taken in even smaller amounts for microdosing. Despite widespread use, no fatal human overdoses have been documented. LSD is mainly used recreationally or for spiritual purposes. LSD can cause mystical ex…

Evidence: 32 • authority: 72

2C (2C-x) is a general name for the family of psychedelic phenethylamines containing methoxy groups on the 2 and 5 positions of a benzene ring. Most of these compounds also carry lipophilic substituents at the 4 position, usually resulting in more potent and more metabolically stable and longer acting compounds. Most of the early 2C drugs were developed by Alexander Shulgin in the 1970s and 1980s and were reviewed in his 1991 book PiHKAL (Phenethylamines I Have Known And Loved). 2C-B is the most popular of the 2C drugs. The prefix "2C" comes from the fact that they are phenethylamines rather than amphetamines and have two carbon atoms in their side chain, whereas the suffix (e.g., the "–B"…