infrastruktura: Artemisinin

Evidence: 100 • authority: 72

Artemisinin () and its semisynthetic derivatives are a group of drugs used in the treatment of malaria due to Plasmodium falciparum. It was discovered in 1972 by Tu Youyou, who shared the 2015 Nobel Prize in Physiology or Medicine for her discovery. Artemisinin-based combination therapies (ACTs) have become standard treatment worldwide for P. falciparum malaria as well as malaria due to other species of Plasmodium. Artemisinin can be extracted from the herb Artemisia annua (sweet wormwood), which is used in traditional Chinese medicine. Alternatively, it can be prepared by a semi-synthetic method from a precursor compound that can be produced using a genetically engineered yeast, which is m…

Evidence: 54 • authority: 92

<i>Artemisia annua</i> and Its Derivatives Improve the Refrigerated Shelf Life of Nile Tilapia Fillets.. Artemisia annua contains artemisinin, a sesquiterpene lactone endoperoxide; artemether is a semisynthetic derivative of artemisinin that may offer potential advantages due to its redox-modulating and antimicrobial activities. These compounds have been associated with oxidative-stress modulation and microbial inhibition, making them promising candidates for experimental evaluation in nutritional and post-harvest quality studies. This study evaluated the effect of dietary supplementation with A. annua powder, artemisinin, and artemether on the refrigerated quality of Nile tilap…

Evidence: 45 • authority: 88

Analysis of underivatized artemisinin and related sesquiterpene lactones by high‐performance liquid chromatography with ultraviolet detection. Abstract Introduction Although high‐performance liquid chromatography with ultraviolet detection (HPLC‐PAD) is widely available, it has not been used for artemisinin (1) analysis because of the lack of UV absorption reported for this lactone. Increased Artemisia annua cultivation for production of 1 requires an affordable and reliable method to analyse 1 and its precursors dihydroartemisinic acid (2) and artemisinic acid (3) simultaneously from underivatized plant extracts. Objective To validate HPLC‐PAD for the quantification of underivatized artemi…

Evidence: 45 • authority: 80

Pharmacological Potentials of Artemisinin and Related Sesquiterpene Lactones: Recent Advances and Trends

Evidence: 45 • authority: 92

Advances in Naturally and Synthetically Derived Bioactive Sesquiterpenes and Their Derivatives: Applications in Targeting Cancer and Neurodegenerative Diseases.. Sesquiterpenes are a diverse class of natural products that have garnered considerable interest for their potent bioactivity and structural variability. This review highlights advances in the derivatization of various sesquiterpene lactones, quinones, and alcohols, particularly in targeting cancer and neurodegenerative diseases. The structural modifications discussed include the incorporation of triazole, arylidene, or thiol moieties with eudesmane, guaiane, and germacranolide-type sesquiterpenes, among others. In addition, the con…

Evidence: — • authority: 80

Sesquiterpene lactones, geranylnerol and tremetone derivatives from Ageratina species

Evidence: — • authority: 80

New Sesquiterpene Lactones From the Genera Calea and Berlandiera (Asteraceae) and the Fragmentation Reactions of 1,3-Dihydroxyeudesmanolide Derivatives.

Evidence: — • authority: 88

Sesquiterpene lactones and their derivatives : extraction, synthesis and structure-activity relationship studies. Lactones sesquiterpéniques et leurs dérivés : extraction, synthèse et études des relations structure-activité Ce travail porte sur la préparation de nouveaux dérivés de Tagitinine C et le dépôt de Tagitinine C et de Vinblastine sur du graphène. L'évaluation des activités biologiques de ces nouveaux composés a été étudiée. Dans la première partie de mon travail de thèse, nous avons décrit l'extraction et l'isolement de la Tagitinine C. La structure de la Tagitinine C a été confirmée par des méthodes d'analyse physico-chimique classique comme IR, RMN et MS. Ces données d'analyse s…