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koty: Morphine

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Morphine was first isolated in 1804 by German pharmacist Friedrich Sertürner.
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Morphine, formerly known as morphium, is an opiate found naturally in opium, a dark brown resin produced by drying the latex of opium poppies (Papaver somniferum). It is mainly used as an analgesic (pain medication). There are multiple methods used to administer morphine: oral; sublingual; via inhalation; injection into a muscle, injection under the skin, or injection into the spinal cord area; transdermal; intravenously; or via rectal suppository. It acts directly on the central nervous system (CNS) to induce analgesia and alter perception and emotional response to pain. Physical and psychological dependence and tolerance may develop with repeated administration. It can be taken for both acute pain and chronic pain and is frequently used for pain from myocardial infarction, kidney stones, and during labor. Its maximum effect is reached after about 20 minutes when administered intravenously and 60 minutes when administered by mouth, while the duration of its effect is 3–7 hours. Long-acting formulations of morphine are sold under the brand names MS Contin and Kadian, among others. Generic long-acting formulations are also available. Common side effects of morphine include drowsiness, euphoria, nausea, dizziness, sweating, and constipation. Potentially serious side effects of morphine include decreased respiratory effort, vomiting, and low blood pressure. Morphine is highly add…
Kategoria: koty
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Jakość źródła: 65/100
Próby weryfikacji: 3
Notatka fact-checku: Fact-check 3.0-content-aware: no sufficient claim-bound corroboration after 3 healthy attempts. Scope=verify the factual claim. Required independent sources=2; stored evidence groups=1. Provider/API errors did not consume attempts. | Fact-check 4.3.2: research wznowiony bez zdejmowania HOLD. Poprzednia metoda: factcheck-300-content-aware. | Fact-check 4.3.2: research wznowiony bez zdejmowania HOLD. Poprzednia metoda: factcheck-weekly-research-432.

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Europe PMC / International journal of molecular sciencesPOTWIERDZAniezależne

Evidence: 65 • authority: 92

Morphinan Alkaloids and Their Transformations: A Historical Perspective of a Century of Opioid Research in Hungary.. The word opium derives from the ancient Greek word ὄπιον (ópion) for the juice of any plant, but today means the air-dried seed capsule latex of Papaver somniferum . Alkaloid chemistry began with the isolation of morphine from crude opium by Friedrich Wilhelm Adam Sertürner in 1804. More than a century later, Hungarian pharmacist János Kabay opened new perspectives for the direct isolation of morphine from dry poppy heads and straw without the labor-intensive harvesting of opium. In 2015, Kabay's life and achievements obtained official recognition as constituting a «Hungariku…

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Europe PMCPOTWIERDZAniezależne

Evidence: 53 • authority: 92

<span style="color: windowtext;">Morphinan Alkaloids and Their Transformations: A Historical Perspective of a Century of Opioid Research in Hungary<sup> †</sup>. The word opium derives from ancient Greek word ὄ&pi;&iota;&omicron;&nu; (&oacute;pion) for the juice of any plant, but today means the air-dried seed capsule latex of Papaver somniferum. Alkaloid chemistry began with the isolation of morphine from crude opium by Friedrich Wilhelm Adam Sert&uuml;rner in 1804. More than a century later, the Hungarian pharmacist J&aacute;nos Kabay opened new perspectives for the direct isolation of morphine from dry poppy heads and straw without the labor-intensive harvesting of opium. In 2015, Kabay&…

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Wikipedia ENpomocniczeniezależne

Evidence: 88 • authority: 72

Friedrich Wilhelm Adam Sertürner (German pronunciation: [ˈfʁiːdʁɪç ˈvɪlhɛlm ˈʔaːdam ˈzɛʁtʏʁnɐ]; 19 June 1783 – 20 February 1841) was a German pharmacist and a pioneer of alkaloid chemistry. He is best known for his discovery of morphine, which he isolated from opium in 1804, and for conducting tests, including on himself, to evaluate its physiological effects.

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Wikipediapomocnicze

Evidence: — • authority: 65

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