Ciekawostka: It has been estimated that humans use only 10% of their brain

Evidence: 45 • authority: 92

US population-level model of clinical impact of lorlatinib treatment on ALK+ metastatic non-small cell lung cancer outcomes.. Aim: Lorlatinib and alectinib are next-generation anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors (TKIs) approved for the treatment of ALK-positive (ALK+) advanced/metastatic non-small cell lung cancer (NSCLC) after demonstrating superior efficacy over crizotinib (first-generation ALK TKI) in the CROWN and ALEX trials, respectively. This analysis estimated the US population-level clinical impact of first-line (1L) lorlatinib versus alectinib treatment for ALK+ advanced/metastatic NSCLC. Materials & methods: We developed a decision-analytic model comparing…

Evidence: 45 • authority: 72

Brain Damage is a 1988 American comedy horror film written and directed by Frank Henenlotter. It stars Rick Hearst in his debut acting role as Brian, a young man who becomes acquainted with a talking parasite known as Aylmer (voiced by John Zacherle) that injects him with an addictive fluid that causes euphoric hallucinations; in return, Aylmer demands that Brian allow him to feed on the brains of other humans. Produced on a budget of under $2 million, Brain Damage is the second feature film directed by Henenlotter, following Basket Case (1982). Principal photography and filming on Brain Damage took place in Manhattan, New York City, in 1987. The film has been characterized as containing th…

Evidence: 35 • authority: 80

Trump wants to use the Alien Enemies Act to deport immigrants – but the 18th-century law has been invoked only during times of war

Evidence: 35 • authority: 92

Corticosteroid Use and In-Hospital Mortality in Patients With Brain Abscess: A Target Trial Emulation.. Purpose Corticosteroids are sometimes administered to patients with severe brain edema associated with brain abscess. However, no studies have used methods that appropriately account for time-varying covariates and immortal time to evaluate the impact of intravenous corticosteroid use on in-hospital mortality. Therefore, we aimed to address these limitations and estimate the impact on in-hospital mortality using a target trial emulation framework. Methods We identified patients admitted with brain abscess, not caused by head trauma or neurosurgical interventions, from two large-scale hosp…

Evidence: 35 • authority: 72

Aging brain refers to biological and functional changes that occur in the brain as individuals advance in age. It encompasses both the normal alterations which are universally experienced and abnormalities induced by illnesses, diagnosed or not. The concept is most often used in relation to humans. Since life extension is only pertinent if accompanied by healthspan extension, and, more importantly, by preserving brain health and cognition, finding rejuvenating approaches that act simultaneously in peripheral tissues and in brain function is a key strategy in the development of rejuvenation technology. Aging is a major risk factor for most common neurodegenerative diseases, including mild co…

Evidence: 35 • authority: 72

The size of the brain is a frequent topic of study within the fields of anatomy, biological anthropology, animal science and evolution. Measuring brain size and cranial capacity is relevant both to humans and other animals, and can be done by weight or volume via MRI scans, by skull volume, or by neuroimaging intelligence testing. The relationship between brain size and intelligence has been a controversial and frequently investigated question. In 2021 scientists from Stony Brook University and the Max Planck Institute of Animal Behavior published findings showing that the brain size to body size ratio of different species has changed over time in response to a variety of conditions and eve…

Evidence: — • authority: 35