Kot: The cat has 500 skeletal muscles (humans have 650)

Evidence: 45 • authority: 80

“Insulinergic” nerves to the skeletal muscles of the cat?

Evidence: 41 • authority: 72

Muscle spindles are stretch receptors within the body of a skeletal muscle that primarily detect changes in the length of the muscle. They convey length information to the central nervous system via afferent nerve fibers. This information can be processed by the brain as proprioception. The responses of muscle spindles to changes in length also play an important role in regulating the contraction of muscles, for example, by activating motor neurons via the stretch reflex to resist muscle stretch. The muscle spindle has both sensory and motor components. Sensory information conveyed by primary type Ia sensory fibers which spiral around muscle fibres within the spindle, and secondary type II…

Evidence: 41 • authority: 80

The number and variety of proprioceptors in certain muscles of the cat

Evidence: 41 • authority: 92

Protocol for transcriptional profiling of fiber type and regeneration markers in mouse Tibialis Anterior muscle.. Skeletal muscle integrity and function depend on fiber-type composition and regenerative capacity. Evaluating both components in normal and injured tissues provides valuable insights into subtle declines in muscle function and recovery. We describe a protocol for the transcriptional analysis of the major fast-twitch type II myofibers and regeneration-related genes in normal and local-injured mouse Tibialis Anterior skeletal muscles. We describe steps for integrating freeze-induced injury, sample collection, tissue dissociation, RNA extraction, and gene expression analysis by qua…

Evidence: 41 • authority: 92

Comprehensive transcriptomic profiling reveals impaired polyamine metabolism as a contributor to age-related muscle decline.. Sarcopenia, the age-related decline in skeletal muscle mass and function, profoundly affects skeletal muscle structure and performance. We present a spatial transcriptomic atlas of skeletal muscle from young and aged mice, resolving transcriptional reprogramming across fiber types and tissue compartments. Our analyses reveal alterations in sarcomeric organization, excitation-contraction coupling, oxidative stress responses, and fiber type-specific metabolic rewiring. Conserved molecular signatures across muscles and species highlight Car3 as a potential biomarker of…

Evidence: 41 • authority: 80

Force Depression/Enhancement in Skeletal Muscles

Evidence: 41 • authority: 80

Denervation of Cat Fast- and Slow-Skeletal Muscles: Effect on Ouabain Binding

Evidence: 41 • authority: 80

A skeletal framework artificial hand actuated by pneumatic artificial muscles

Evidence: 41 • authority: 92

FAP-derived CCL2 is required for adequate monocyte/macrophage infiltration to support acute skeletal muscle injury repair.. Repair of acutely injured skeletal muscle relies on an adequate inflammatory response predominated by monocyte/macrophage infiltration. The process requires injured muscles to produce C-C chemokine ligand 2 (CCL2). The present study identified fibro/adipogenic progenitors (FAPs) as the primary source of CCL2 in acutely injured muscle, where the pro-inflammatory subcluster of FAPs expanded rapidly and expressed the highest level of CCL2. FAP-specific deletion of Ccl2 largely abolished CCL2 production by acutely injured muscle, reducing monocyte/macrophage infiltration a…

Evidence: 41 • authority: 92

Pik3ip1 mediates thyroid hormone-dependent regulation of the PI3K/Akt/mTOR axis in muscle atrophy.. Skeletal muscle atrophy is driven by an imbalance between anabolic and catabolic signaling pathways, often involving suppression of the PI3K/Akt/mTOR axis. Thyroid Hormones (THs) are key endocrine regulators of skeletal muscle metabolism and adaptation, exerting context-dependent effects that promote either muscle atrophy or hypertrophy. Here, we identify Phosphoinositide-3-kinase interacting protein 1, Pik3ip1, as a critical regulator of TH-dependent muscle homeostasis. Transcriptomic profiling of skeletal muscle from muscle-specific D2 knockout (mD2KO) and TH Receptor knockout (TRKO) mice r…

Evidence: 41 • authority: 72

Toxoplasmosis is a parasitic disease caused by Toxoplasma gondii, an apicomplexan. Infections with toxoplasmosis are associated with a variety of neuropsychiatric and behavioral conditions. Occasionally, infected individuals may experience a few weeks or months of mild, flu-like illness such as muscle aches and tender lymph nodes. In a small number of people, eye problems may develop. In those with a weakened immune system, severe symptoms such as seizures and poor coordination may occur. If a woman becomes infected during pregnancy, a condition known as congenital toxoplasmosis may affect the child. Toxoplasmosis is usually spread by eating poorly cooked food that contains cysts, by exposu…

Evidence: — • authority: 38